解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Neurotrophins regulate many aspects of neuronal function through activation of the high affinity Trk receptors. Shc family proteins are implicated in the coupling of RTK to the Ras/mitogen-activated protein kinase signaling cascade. Here we report that the fourth Shc family member, ShcD, associates with TrkB receptor ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.7.485
更新日期:2010-07-01 00:00:00
abstract::Homeodomain (HD) is a highly conserved DNA-binding domain composed of helix-turn-helix motif. Drosophila Vnd (Ventral nervous system defective) containing HD acts as a regulator to either enhance or suppress gene expression upon binding to its target sequence. In this study, kinetic analysis of Vnd binding to DNA was ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.6.407
更新日期:2010-06-01 00:00:00
abstract::The sterile alpha motif (SAM) is a putative protein interaction domain involved in a wide variety of biological processes. Here we report the identification and characterization of a novel gene, SAMD4B, which encodes a putative protein of 694 amino acids with a SAM domain. Northern blot and RT-PCR analysis showed that...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.5.355
更新日期:2010-05-01 00:00:00
abstract::The aim of work was to investigate changes of 7-ketocholesterol synthesis in alveolar macrophages in the dynamic of lung mechanical ventilation with injurious parameters. The goal of in vitro part of work was to observe influence of 7-ketocholesterol on iNOS and MIP1 Beta production in bronchoalveolar lavage fluid (BA...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.4.257
更新日期:2010-04-01 00:00:00
abstract::In this study, we report the identification and characterization of a novel C2H2 zinc finger protein, ZNF552, from a human embryonic heart cDNA library. ZNF552 is composed of three exons and two introns and maps to chromosome 19q13.43. The cDNA of ZNF552 is 2.3 kb, encoding 407 amino acids with an amino-terminal KRAB ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.3.193
更新日期:2010-03-01 00:00:00
abstract::A large data set of Hanwoo (Korean cattle) ESTs was analyzed to obtain differential gene expression results for the following three libraries: intramuscular fat, longissimus dorsi muscle and liver. To better understand the gene expression profiles, we identified differentially expressed genes (DEGs) via digital gene e...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.2.115
更新日期:2010-02-01 00:00:00
abstract::In this study, a novel member of BTB-kelch proteins, named KBTBD7, was cloned from a human embryonic heart cDNA library. The cDNA of KBTBD7 is 3,008 bp long and encodes a protein product of 684 amino acids (77.2 kD). This protein is highly conserved in evolution across different species. Western blot analysis indicate...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2010.43.1.017
更新日期:2010-01-01 00:00:00
abstract::The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced n...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.12.794
更新日期:2009-12-31 00:00:00
abstract::The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizing radiation (IR)-induced DNA damage response. RAP80 translocates to sites of IR-induced DNA damage through interaction of its UIM domain with ubiquitinated H2A and Lys6...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.11.764
更新日期:2009-11-30 00:00:00
abstract::Our understanding of the relationships between genes, brains, and behaviors has changed a lot since the first behavioral mutants were isolated in the fly bottles of the Benzer lab at Caltech (1), but Drosophila is still an excellent model system for studying the neurobiology of behavior. Recent advances provide an unp...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2009.42.11.705
更新日期:2009-11-30 00:00:00
abstract::The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibito...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.10.655
更新日期:2009-10-31 00:00:00
abstract::The bactenecin is an antibacterial peptide with an intramolecular disulfide bond. We recently found that homodimeric bactenecin exhibits more potent antibacterial activity than the monomeric form and retains its activity at physiological conditions. Here we assess the difference in the modes of antibiotic action of ho...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.9.586
更新日期:2009-09-30 00:00:00
abstract::Phosphomannose isomerase (PMI) catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate in the extracellular polysaccharide (EPS) synthesis pathway. The gene encoding PMI in Sphingomonas chungbukensis DJ77 was cloned and expressed in E. coli. The pmi gene is 1,410 nucleotides long and the deduced ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.8.523
更新日期:2009-08-31 00:00:00
abstract::Orthodontic tooth movement results from the combinational process of both bone resorption and formation in the compressive and tension sides, respectively. However, the genes responsible for new bone formation in tension sides have not been determined. In this study, we used DNA microarray and real-time RT-PCR to iden...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.7.427
更新日期:2009-07-31 00:00:00
abstract::We investigate the correlation between the glycosylation modified prion proteins and apoptosis. The wild-type PRNP gene and four PRNP gene glycosylated mutants were transiently expressed in HeLa cells. The effect of apoptosis induced by PrP mutants was confirmed by MTT assay, Hochest staining, Annexin-V staining and P...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.6.331
更新日期:2009-06-30 00:00:00
abstract::Sweetpotato (Ipomoea batatas (L). Lam.) is relatively tolerant to unfavorable growth conditions such as drought, yet has not been exploited to provide a better understanding of the molecular basis of drought stress tolerance. We obtained 983 high-quality expressed sequence tags of 100 bp or longer (average length of 7...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.5.271
更新日期:2009-05-31 00:00:00
abstract::During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis. Among these proteins...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2009.42.4.189
更新日期:2009-04-30 00:00:00
abstract::Small-molecule inhibitors of protein kinases have contributed immensely to our understanding of biological signaling pathways and have been exploited therapeutically for the treatment of cancers and other disease states. The pyridinyl imidazole compounds SB 203580 and SB 202190 were identified as ATP competitive antag...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.3.142
更新日期:2009-03-31 00:00:00
abstract::Aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. This study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma U937 cells. Ar-turmerone treatment inhibited U937 cell viability in a concentration-dependent fashion, ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.2.096
更新日期:2009-02-28 00:00:00
abstract::To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta(1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized. Southern blot analysis of BnP5CSs in B. napus and its...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2009.42.1.028
更新日期:2009-01-31 00:00:00
abstract::Protein phosphatase 1 consists of a secondary structure arrangement, conserved in the serine/threonine protein phosphatase gene family, flanked by nonconserved N-terminal and C-terminal domains. The deletion mutant of PP1 with the 8 nonconserved N-terminal residues removed was designated PP1-(9-330). PP1-(9-330) had a...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.12.881
更新日期:2008-12-31 00:00:00
abstract::Mac-2BP is a ligand of the galectin family that has been suggested to affect tumor proliferation and metastasis formation. We assessed Mac-2BP expression at the transcriptional and translational levels to evaluate nerve growth factor (NGF)-induced Mac-2BP expression. A time kinetic analysis using reverse transcription...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.11.784
更新日期:2008-11-30 00:00:00
abstract::FoxO3a is a member of the forkhead box class O (FoxO) transcription factor family and an important regulator of apoptosis. This work aimed to elucidate the involvement of FoxO3a in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in FaO rat hepatoma cells. TGF-beta1 caused a time-dependent activation of ...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.10.728
更新日期:2008-10-31 00:00:00
abstract::The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl(2)) was chosen as the source of Cd. Experimental animals were treated with either CdCl(2) alone or taurine, followed b...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.9.657
更新日期:2008-09-30 00:00:00
abstract::The importance of lipids in cell signaling and tissue physiology is demonstrated by the many CNS pathologies involving deregulated lipid metabolism. One such critical metabolic event is the activation of phospholipase A(2) (PLA(2)), which results in the hydrolysis of membrane phospholipids and the release of free fatt...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2008.41.8.560
更新日期:2008-08-31 00:00:00
abstract::The interaction of the rod GTP binding protein, Transducin (G(t)), with bleached Rhodopsin (R(*)) was investigated by measuring radiolabeled guanine nucleotide binding to and release from soluble and/or membrane-bound G(t) by reconstituting G(t) containing bound GDP (G(t-)GDP) or the hydrolysis-resistant GTP analog gu...
journal_title:BMB reports
pub_type: 杂志文章
doi:
更新日期:2008-07-31 00:00:00
abstract::IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expres...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.6.461
更新日期:2008-06-30 00:00:00
abstract::The Pphsc70 (heat shock cognate 70) gene was isolated from the endoparasitoid Pteromalus puparum and then characterized. The full-length cDNA was 2204 base pair (bp) and contained a single 1968 bp ORF that encoded a polypeptide of 656 amino acids with a predicted molecular mass of 71.28 kDa. Phylogenetic analysis base...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.5.388
更新日期:2008-05-31 00:00:00
abstract::The Dazl gene encodes a germ-cell-specific RNA-binding protein which is essential for spermatogenesis. It has been proposed that this protein (DAZL) binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. Using the specific nucleic acids associated with proteins (SNAAP) technique, we identified 17 ta...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.4.300
更新日期:2008-04-30 00:00:00
abstract::Stresses and nutritional starvation are two main external signals for the induction of sex pheromones in the fission yeast Schizosaccharomyces pombe. In an attempt to identify the components involved in transduction of starvation signals, we screened 135 temperature-sensitive (ts) mutants and isolated 6 mutants that i...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.3.248
更新日期:2008-03-31 00:00:00
abstract::Ubiquitin is an essential, highly-conserved small regulatory protein in eukaryotic cells. It covalently modifies a wide variety of targeted proteins in the forms of monomer and polymers, altering the conformation and binding properties of the proteins and thus regulating proteasomal delivery, protein activities and lo...
journal_title:BMB reports
pub_type: 杂志文章,评审
doi:10.5483/bmbrep.2008.41.3.177
更新日期:2008-03-31 00:00:00
abstract::We cloned and pharmacologically characterized the guinea pig cysteinyl leukotriene (CysLT) 2 receptor (gpCysLT2). gpCysLT2 consists of 317 amino acids with 75.3%, 75.2%, 73.3% identity to those of humans, mice and rats, respectively. The gpCysLT2 gene is highly expressed in the lung, moderately in eosinophils, skin, s...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.2.139
更新日期:2008-02-29 00:00:00
abstract::PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand inter...
journal_title:BMB reports
pub_type: 杂志文章
doi:10.5483/bmbrep.2008.41.1.048
更新日期:2008-01-31 00:00:00